She was encouraged to take the sport of skiing by her elder sister, Aleksandra Lysova, in 2002 when she was just ten years old though her parents did not like it.

[6] Mikhalina Lysova was also the flagbearer for Russia at the closing ceremony during the 2014 Winter Paralympics.

[10] In April 2018 after the conclusion of the 2018 Winter Paralympics on 18 March 2018, a German daily newspaper called Bild, falsely claimed Mikhalina Lysova for doping by blaming her for being indifferent to fellow Russian athletes who have been caught for doping issues and also filed a complaint against her at a court.

[11] The newspaper also believed that Mikhalina would have used banned substances to boost her performance at the 2018 Winter Paralympics where she managed to pick up 5 medals.

[12] However, Mikhalina Lysova managed to prove herself as an honest and innocent person after winning the court case against the German newspaper.