She was discovered by LVN Pictures President Doña Sisang de Leon, who insisted in casting her over the objections of the film's director, who felt she was too young for the part.

Del Sol returned to LVN and starred in its production of Manuel Conde's Orasang Ginto, the first post-war Filipino film.

Del Sol appeared in three films in 1938 (including Ang Maya opposite Fernando Poe, Sr.), but got her big break as a principal character in the 1939 classic Giliw Ko, for which she was honored by then Philippine President Manuel L.

She made twelve other films for LVN during this period, including Hali (1940), an early example of the Sarong genre, and Sawing Gantimpala (1940), which was based on a song written for del Sol by First Lady Aurora Quezon.

Del Sol volunteered for the Red Cross, and frequented Prisoner of War camps along with other "Blue Ladies" of the Philippine film industry.

She made more than twenty other films during this period including Garrison 13 (1946), which recounted atrocities committed by the Imperial Japanese Army in the Philippines during the war.

Del Sol acted opposite all the male leads of her period, including Teddy Benavídez, Fred Cortes, Armando Goyena, Fernando Poe, Sr., José Padilla, Jr., Ely Ramos, Jaime de la Rosa, Rogelio de la Rosa, and Leopoldo Salcedo.

Del Sol is the mother of Filipina actress and television host Jeanne Young, non-profit professionals Ancel Edgar Romero and Leo John Romero, grandmother of famed musician Ira Cruz, Philippine Congressman Gustavo Tambunting of Parañaque, actor Onemig Bondoc,[11] and aunt of Former Mayor of Muntinlupa Ignacio Bunye.