The management of the railway and of the station is performed by FerrovieNord S.p.A., a society of the FNM group, which will hold authority until March 17, 2016, thanks to renewed concessions with the Decreto Dirigenziale del Ministero dei Trasporti e della Navigazione n. 3239/2000.

The engineer Ambrogio Campiglio wrote up the proposal to create a connection between the Saint Peter Martyr station of Seveso and the one in Camnago on Milan-Chiasso line.

The railway line was officially inaugurated on December 31, 1879, although in the previous months many sections were opened to the traffic as they were completed and tested.

In 1887, thanks to a Società per le Strade Ferrate del Mediterraneo's request about the necessary enlargement of the freight of Milan Porta Sempione, Ferrovie Nord lowered to the trench level the line which crossed the old section between the old Central Station (situated where currently there's Milano Repubblica station) and the Milan Porta Genova.

In the meanwhile, because of the technical impossibility in reaching Asso, the station of Canzo-Asso was opened (in Canzo's territory) in order to serve the neighboring comune and the Valassina.

Trains which made service on the whole line changed traction from electrical to steam in Seveso, because Meda didn't have a turntable.

Meda-Erba was opened with the new traction on December 3, 1947, followed by Erba-Asso on January 20, 1948, always without waiting for the formal concession by the Italian government.

In 1999 started works in order to quadruple the section Milan Cadorna-Milan Bovisa, completed eight years later and inaugurated on September 9, 2007.

Interventions are about the elimination of level crossings, the modernization of some stations on the line, the realization of the third rail between Milan Affori and Varedo and the double of the section between Seveso and Mariano Comense.

The traffic on the section Seveso-Asso is ruled by the Dirigente Centrale Operativo (DCO) and its office is at Seveso railway station.

From Mariano starts the greenest track of the line which undertakes a long straight until Carugo-Giussano and, after a detected turn, Arosio, which station stay in front of the Parish Church.

Trains with a full of curves cross a hilly area, in order to reach Inverigo station, panoramic place defined "Brianza's balcony", where it is possible enjoy about a very beautiful landscape.

After a corner, trains cross Lambro river in order to reach the closed Lezza-Carpesino station, which take the name from the districts where it is situated.

From Caslino d'Erba trains go across a steep ramp, with the 26 per 1000 inclination, in order to reach a rilevato where convoys go until the first Canzo station.

At the end, after having crossed Grimello tunnel, trains reach Canzo-Asso terminal, on Canzo territory, near Lambro river which, in correspondence with the branch waterfall Vallategna, divide two municipalities and, above all, it separate Brianza from Vallassina.

[1] Because of lacks of infrastructures and works in progress along the line, services are not in the true regime according to theorical criterion which define Lombard suburban and regional railway service features: for example, S2 and S4 lines are not equally spaced out, but are scheduled at 10-20 minutes intervals, in order to allow for enough space for the regional trains, which do not call at most suburban stations .

The future implementation should provide one S2 and S4 run evenly spaced out, every 15 minutes, with the speeding of the regional one, which today must stop in some stations of suburban contest.