[4] On 10 October 1849 line was opened from Monza to Camnago in Lentate sul Seveso and it was extended to Camerlata on 6 December.

[4] It was part of the Società per le strade ferrate dell'Alta Italia (Upper Italian Railways) from 1865, the Società per le Strade Ferrate del Mediterraneo (Mediterranean Railway Company) from 1885 and Ferrovie dello Stato from 1905.

From 12 December 2004 regional passenger trains had been operated by TiLo ("Treni Regionali Ticino Lombardia", a joint venture of Ferrovie dello Stato and Swiss Federal Railways).

The section beteween Milan and Monza is also used by lines S7 and S8 of Milan suburban network to Lecco, respectively via Molteno and via Carnate, regional trains to Bergamo and RegioExpress trains to Lecco, Sondrio and Tirano, while the short section beteween Como and Chiasso is used by lines S10 and S40 of the "Rete celere ticinese", managed by TiLo.

In 2019, integrated tickets were extended to include every form of public transport in Monza-Brianza and Milano provinces.