Milešov is a municipality and village in Příbram District in the Central Bohemian Region of the Czech Republic.

Milešov consists of three municipal parts (in brackets population according to the 2021 census):[2] Milešov is located about 19 kilometres (12 mi) southeast of Příbram and 50 km (31 mi) south of Prague.

[3] The village was founded in the 14th century as a result of gold and antimony mining in the area.

The main historical landmark of Milešov is the Church of the Assumption of the Virgin Mary.

[7] Destinov Mansion was built in the mid-19th century for Emanuel Kittl, who owned local mines and is known as the father of Emmy Destinn.