In 1381 an uprising against the tax collectors of Brentwood quickly spread; firstly in the surrounding villages and then throughout the South-East of England.

On 14 June, the teenaged King Richard II rode to Mile End where he met the rebels and signed their charter.

In 1811 Bancroft Road Cemetery at Globe Fields was opened for its first burial by the separatist "Maiden Lane synagogue in Covent Garden".

Also in June 1990 the Bancroft Unit for the Care of the Elderly opened at Mile End Hospital having moved from Bethnal Green.

This coincided with a project by the philanthropist businessman Edmund Hay Currie to use money from the winding up of the "Beaumont Trust",[11] (together with subscriptions) to build a "People's Palace" in the East End.

The complex had a library, swimming pool, gymnasium and winter garden by 1892 which provided an eclectic mix of populist entertainment and education.

In 1946 (as part of the Central line eastern extension) the station was expanded and rebuilt by Stanley Heaps (Chief Architect of London Underground) and his assistant Thomas Bilbow.

It was paid for by Henry Fitzalan-Howard, 15th Duke of Norfolk as a memorial to his youngest sister Lady Margaret Howard, who had performed charitable work in the East End.

[17] As well as suffering heavily in earlier blitzes, Mile End was hit by the first V-1 flying bomb to strike London.

On 13 June 1944, that "doodlebug" impacted next to the railway bridge on Grove Road, an event now commemorated by a blue plaque.

It is a large Conservation Area with an irregular shape that encloses buildings around Mile End Road, Assembly Passage, Louisa Street and Stepney Green itself.

[21] On 17 June 1995, the Mile End Stadium hosted a gig by Britpop band Blur where 27,000 fans saw them supported by the Boo Radleys, Sparks, John Shuttleworth, Dodgy and the Cardiacs.

[22] A groundbreaking project funded by the Millennium Commission called the Green Bridge opened in 2000 (a pedestrian and cyclist separation structure over the A11 (Mile End Road) connecting the two halves of Mile End Park to form a linear park).

[25] Since 2016, northern Mile End has fallen under the remit of the Bow Roman Road Neighbourhood Forum.

It was sold to Trustee Properties Ltd who obtained permission from Tower Hamlets Council in 2017 to develop five flats but not to demolish the ground floor of the pub.

[27] Mile End formed a hamlet within the large ancient parish of Stepney, in the Tower division of the Ossulstone hundred of Middlesex.

Upon the creation of the Metropolitan Board of Works in 1855 the vestry of Mile End Old Town became an electing authority.

The neighbourhood was depicted unfavourably in the pop band Pulp's 1995 song "Mile End", which was featured on the Trainspotting soundtrack.

[32] In 2011, the music video for "Heart Skips a Beat" by Olly Murs and Rizzle Kicks was filmed in Mile End's skate park.

The Central line also links the area directly to Stratford and Essex in the east and London's West End.

At Stratford, the road meets the A12 where eastbound traffic can continue towards Ilford, the M11 (for Stansted Airport) and destinations in Essex.

The London Borough of Tower Hamlets monitors roadside air quality in Mile End.

In 2017, average Nitrogen Dioxide (NO2) levels in the locale failed to meet the UK National Air Quality Objective of 40μg/m3 (micrograms per cubic metre).

Alternative monitoring sites on Mile End Road also failed to meet air quality objectives.