Mile Isaković (Serbian Cyrillic: Миле Исаковић; born 17 January 1958) is a Serbian handball coach and former player who competed for Yugoslavia in the 1980 Summer Olympics and in the 1984 Summer Olympics.

Born in Šabac, Isaković started out at his hometown club Metaloplastika.

He was an instrumental member of the team that won the gold medal at the 1984 Summer Olympics.

Subsequently, Isaković helped Yugoslavia win the gold medal at the 1986 World Championship.

In 1991, Isaković started his coaching career at French club OM Vitrolles.