A power forward, Topić spent most of his professional career playing in the YUBA League, representing Profikolor, BFC Beočin, Crvena zvezda, Budućnost, and Hemofarm.

In the later career, he also played in Italy for Montepaschi Siena and Olimpia Milano, as well as in Greece for Rethymno, until his retirement in 2008.

[3] He was a member of the Yugoslavia team that won the gold medal at the 1998 FIBA World Championship in Athens, Greece.

[5] Topić spent the 2015–16 season working as an assistant coach for the Hungarian team SZTE-Szedeák.

In June 2020, Nikola signed a scholarship contract with the Crvena zvezda youth system.