[8][9] It was also featured on the Make magazine blog[10] The Milkymist One board was included in their "Ultimate open source hardware gift guide 2010".

The LM32 microprocessor is assisted by a texture mapping unit and a programmable floating point VLIW coprocessor, which are used by the Flickernoise video synthesis software.

[13] It was first sold at the Chaos Communication Congress in 2010,[14] as an "early developer kit" for interested hackers, open source activists, and pioneers who could tolerate the remaining software and FPGA design shortcomings.

The software supports the programming of visual effects that transform a live video stream coming from a camera connected to the Milkymist One, as well as input from OpenSoundControl, DMX512, and MIDI controllers.

[17][18] The system, called ARTIQ (Advanced Real-Time Infrastructure for Quantum physics), is a combination of software and gateware that enables synchronized control of many devices with nanosecond-level timing resolution and sub-microsecond latency, while retaining features of high level programming languages.

In 2016 M-Labs partnered with ARL and ISE to develop ARTIQ Sinara, an open source hardware and software-defined radio platform.