[5] The cast featured David Lago as Elvis Presley, Gabe Bowling as Carl Perkins, Sean Sullivan as Johnny Cash, Lance Lipinsky as Jerry Lee Lewis, Tim Decker as Sam Phillips, and Kelly Lamont as Dyanne.

[6] The Broadway production premiered at the Nederlander Theatre on April 11, 2010,[7] with a cast featuring Eddie Clendening as Elvis Presley, Lance Guest as Johnny Cash, Levi Kreis as Jerry Lee Lewis, Robert Britton Lyons as Carl Perkins and Hunter Foster as Sam Phillips.

[8] The Broadway cast also included Elizabeth Stanley as "Dyanne",[9] who in the show accompanies Elvis Presley to the Sun Records studio and sings "Fever" and "I Hear You Knocking", as well as provides back-up vocals.

[15][16] The original cast featured Bill Ward as Sam Phillips, Ben Goddard as Jerry Lee Lewis, Derek Hagen as Johnny Cash, Francesca Jackson as Dyanne, Robert Britton Lyons as Carl Perkins (However, from March 2011, he was replaced by Oliver Seymour-Marsh who was originally the first understudy for the same role), and Michael Malarkey as Elvis Presley.

[14] The show had struggled at the box office in final months of the Broadway production, taking in $242,786 out of a potential $1,109,700 and playing to 36.76% of capacity for the week ending June 5, 2011.

[20] The cast for Million Dollar Quartet at New World Stages features Eric Stang (Jerry Lee Lewis), Eddie Clendening (Elvis Presley), Lance Guest (Johnny Cash), Robert Britton Lyons (Carl Perkins), Victoria Matlock (Dyanne), James Moye (Sam Phillips), Corey Kaiser (Jay Perkins) and Don Peretz (Fluke).

[22] The tour cast features Derek Keeling as Johnny Cash, Cody Slaughter as Elvis Presley, Martin Kaye as Jerry Lee Lewis, Lee Ferris as Carl Perkins, Christopher Ryan Grant as Sam Phillips, Kelly Lamont as Dyanne, Billy Shaffer as Fluke and Chuck Zayas as Jay Perkins.

It featured Alexander Baerg as Elvis Presley, Dan Kosub as Carl Perkins, Montgomery Bjornson as Jerry Lee Lewis, Jonas Shandel as Johnny Cash, Leon Willey as Sam Phillips, Meaghan Chenosky as Dyanne, Scott Carmichael as Fluke, and Kraig Waye as Brother Jay.

Several notable performers have joined the cast of the show for the encore, including: Melissa Etheridge on June 23, 2010,[26] Jerry Lee Lewis on September 10, 2010,[27] Lesley Gore on October 28, 2010,[28] and Ray Benson on November 16, 2010.

Gifted musicians and likable performers, they tackle with no apparent discomfort the unenviable chore of impersonating some of the most revered names in pop music, from their slick pompadours right down to their frisky, agile fingertips.