Twice winners of the Galway Senior Football Championship, Milltown made a first appearance in a county final in 20 years in 2007, but lost to Killererin at Pearse Stadium in Salthill.

Former Texaco Footballer of the Year, Noel Tierney, one of the members of Galway's historic "Three In a Row" team, would be one of Milltown's best known players.

It also says that an unnamed Milltown captain called for the Harp for Erin as the referee conducted the toss-up leading to the newly named club.

In 1953 they won their first trophy when they beat Ahascragh 1-7 to 2-1 in the Galway Junior North Board Championship Final Replay, drawing the first match with seven points each, however they were stripped of their title and suspended for 12 months for fielding an illegal player, a County Longford man who worked as a barman in a pub in Vicar Street, Tuam.

[citation needed] Two Milltown players were part of the Galway Under 21 All-Ireland winning squad in 2002: Diarmaid Blake and John Devane.

Three more Milltown players were part of the Galway Under 21 All-Ireland winning squad in 2005: Darren Mullahy, Matthew Flannery and Cathal Blake.