It has a level 1 accredited trauma unit, and cardiology and cardio-thoracic services.

[1][2] The hospital also houses the only Gamma Knife unit in South Africa.

Nelson Mandela was treated at the hospital for an acute respiratory infection in January 2011[3] and underwent a laparoscopy there in February 2012.

[4] In February 2009, South African sprinter Oscar Pistorius was treated at the hospital after a serious boating accident.

On 30 July 2021, Botswanan actor Shona Ferguson died at the hospital due to COVID-19 complications.