The renovations also introduced a second-generation laser-illuminated, ultra-high-resolution Laser CineDome projection system, which is only the second to exist in the world and features true 6K resolution playback.

In 1977 the Junior League, National Council of Jewish Women and the Technology club[2] started to plan the opening of this institution.

The original museum, then known as the Discovery Center, opened on November 15, 1981, in a storefront at 321 South Clinton Street in downtown Syracuse.

In 1992, New York State and the federal government accepted The Discovery Center's proposal to open a Museum of Science & Technology in the Armory building.

In 2021,the Museum announced the closure of the IMAX Omnitheater as well as the planetarium as part of a major project to upgrade the theater to digital.