The station is located where Dock Road comes down from downtown Milton to the river's edge, in the midst of a small former industrial area.

The northern two-thirds of the building, the oldest part, sits on a sandstone foundation, while the southern portion rests on masonry piers.

Aesthetically, it reflects the Stick style common in the period of its construction, with its well-integrated forms and flamboyant detailing leaving the building's singular function apparent.

[1] The station site had been actively used for transportation purposes by local Native Americans long before the first [colonists arrived in the 17th century.

When the future Town of Marlborough was settled around 1710, the station site was the boundary between its first two land grants, and some of the first houses were built nearby.

[1] It continued to grow in the early half of the 19th century, becoming a regular steamboat port and the eastern end of the Farmer's Turnpike, which extended out to the foot of the Shawangunk Ridge in Gardiner, New York.

[1] In the 1950s, airplane jet travel and the Interstate Highway System began offering alternatives to railroads, and the last passenger train stopped at Milton in 1958.