[1] The school is situated on the site of the former Priorsdean Hospital for infectious diseases, which was established in 1884.

Miltoncross School opened on a different site in Penhale Road in September 1999, but did not move to the building it is housed in until 2000.

The school is sponsored by The Kemnal Academies Trust, but continues to coordinate with Portsmouth City Council for admissions.

The first headteacher was David Throp, who left after one and a half years; Tim Stokes was then interim head, succeeded by Barry Gransden, then Neil Mcleod, Fiona Calerbank and Nick Giles.

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