Minami-sakurai Station is served by the 62.7 km (39.0 mi) Tobu Urban Park Line (formerly known as the "Tobu Noda Line") from Ōmiya in Saitama Prefecture to Funabashi in Chiba Prefecture, and lies 20.6 km (12.8 mi) from the western terminus of the line at Ōmiya.

On 1 August 1932 it was relocated 400 meters towards Kashiwa and elevated in status to a full station with its present name.

On 6 November 1943, a new station named Yonejima Station (米島駅, Yonejima eki) was established 800 meters in the direction of Kashiwa for freight operations.

[2] In fiscal 2019, the station was used by an average of 14,515 passengers daily.

[3] Media related to Minami-Sakurai Station (Saitama) at Wikimedia Commons