The Ministry of Foreign and European Affairs, Defence, Development Cooperation and Foreign Trade (Luxembourgish: Ministère des Affaires étrangères et européennes, de la Défense, de la Coopération et du Commerce extérieur, MAE), commonly referred to as the Ministry of Foreign Affairs, is a ministry of the government of Luxembourg, which comprises a general secretariat and eight directorates.

For instance, LSAP politicians Jacques Poos and Jean Asselborn served a combined 34 years as Minister of Foreign Affairs in CSV and DP-led governments, 24 of which as Deputy Prime Minister.

The position of Minister for Foreign Affairs has been in continuous existence since the promulgation of Luxembourg's first constitution, in 1848.

Until 1937, the position was held concurrently by the Prime Minister,[2] thus ridding it of any true significance as an office.

Since 24 March 1936, the title of Minister for Foreign Affairs has been an official one, although the position had been unofficially known by that name since its creation.