The Ministry of External Relations (Spanish: Ministerio de Relaciones Exteriores or MIREX) of the Dominican Republic is the government institution in charge of foreign affairs.

[3] Since the early days of the Dominican Republic, the external relations focused on securing a protectorate with a foreign power, be it Spain, France or United Kingdom.

During this period, some of the most distinguished men of the time were in charge of Dominican diplomacy, such as Ulises Espaillat, Pedro Francisco Bonó, Manuel de Jesús Galván, among others.

Ambassador Minerva Bernardino, first female diplomat of the Dominican Republic, signed the Charter of the United Nations in name of the country.

With the 2010 Constitutional reform, the office became the Ministry of External Relations (Ministerio de Relaciones Exteriores) with Decree no.