The Ministry of Foreign Affairs (Spanish: Ministerio de Relaciones Exteriores, MINEX) of Guatemala is the executive office in charge of conducting the international relations of the country.

This ministry can give the Guatemalan nationality, enforces the immigration laws of the country, preserves the national limits and boundaries, negotiates international treaties and agreements with other countries and preserves the copies of the ones signed by Guatemala.

Starting in the 19th century, right after independence from Spain was signed, the public administration was slowly organized.

There was a first stage when Guatemala was a part of the United Provinces of Central America, and a second stage starting in 1847, when Guatemala became an independent, free and sovereign republic to administer its own public affairs.

For that reason, Congress passed a bill for the organization of the Executive Branch, which first spoke of a Foreign Affairs Ministry, on April 25, 1945.