The ministry was established on 1 February 1944, as the People's Commissariat of Foreign Affairs of the Moldavian SSR.

The highest recognition the ministry received was on 23 November 1983, when Foreign Minister Comendant spoke at a meeting of the UN General Assembly.

According to the 1978 Soviet Moldovan Constitution, the international rights of the MSSR were reduced in comparison with the amendments of 1944.

The office of Foreign Minister is one of the most high-profile positions in the Government of Moldova.

The following subdivisions are part of the MFA:[4] Public Relations Department (Birth–Death) Muravschi Sangheli I Ciubuc I Sturza Braghiș Tarlev I Greceanîi I-II Acting Prime Minister Acting Prime Minister Recean