The Ministry of National Defence (Greek: Υπουργείο Εθνικής Άμυνας, abbreviated ΥΠΕΘΑ), is the civilian cabinet organisation responsible for managing the Hellenic Armed Forces, the leader of which is, according to the Constitution (Article 45), the President of the Republic but their administration is exercised only by the Prime Minister and the Government of Greece.

It is considered to be a ministry of particular prestige and is one of the most desirable to the members of each government, because it oversees the Armed Forces, manages huge sums of money, and is usually away from the woes and the wear and tear of everyday life.

Since 27 June 2023, the Minister for National Defence is Nikos Dendias.

It was founded in 1950 from the unification of three Ministries: under the influence of American advisors.

However, a single Ministry of National Defence was established and operated in the three-year period of 1941–44 by the puppet governments[1] (the legitimate exiled Greek government of the Middle East had retained the separate Ministries of Military Affairs, Naval Affairs and Aviation for the free Greek Armed Forces there).