Former major tenants at the mall included Carson Pirie Scott, Donaldson's, Montgomery Ward, Office Depot, Saks Off Fifth Avenue, and Sports Authority.

Unused parts of the anchor tenant were transformed into leasable space for Marshalls and smaller retailers such as Limited Express and Musicland.

[10][11] In January 2015, Saks Fifth Avenue announced plans to open a clearance store at the Minneapolis City Center, relocating from their former 27,000-square-foot (2,500 m2) location at the neighboring Gaviidae Common.

[15] Other tenants leasing space at Minneapolis City Center throughout the decade include Allen Edmonds, Brooks Brothers, Fogo de Chão, and GNC.

[19] Local upscale retailer Len Druskin once occupied several spaces within the shopping center but shuttered all locations in 2017, following a buyout from Lebanese-American businessman Marcus Lemonis.

[20] On July 15, 2018, a customer inside of the basement Marshalls store deliberately set a clothing rack on fire, causing US$500,000 worth of damage to merchandise.

[23] In March 2021, the Target Corporation, a major tenant of 33 South Sixth and an occupant of Minneapolis City Center, announced it would prematurely end its lease.

[25] According to MinnPost's Nick Magrino, the center's brutalist exterior appearance is similar to that of the nearby Riverside Plaza apartment complex.

The mall connects to 50 South Sixth, 700 Nicollet, Gaviidae Common, Mayo Clinic Square, the Plymouth Building, and Radisson Blu Minneapolis Downtown.

[28] On August 1, 2019, the US$3 million renovation began on the mall's eastern facade, beginning with the removal process of precast concrete panels.