Highway 108 passes through the cities of Pelican Rapids and Henning.

Highway 108 serves as an east–west and a north–south route between Interstate 94/US Highway 52, Pelican Rapids, Dent, Perham, Ottertail, and Henning in west-central Minnesota.

The roadway changes direction to north–south as it runs concurrent with State Highway 78 for 9 miles between Perham Township and Ottertail.

Highway 108 is also known as: Maplewood State Park is located 7 miles east of Pelican Rapids on Highway 108 near Lake Lida.

[4] The section of Highway 108 between U.S. 59 at Pelican Rapids and present day Interstate 94 (near Rothsay and Lawndale) was authorized in 1949.