In 2017, the Vixen changed leagues and joined the Women's Football Alliance (WFA) where they continue to compete on a national level.

In 2019, the Vixen were the first women's team to offer live broadcast of all regular season games including both home and away via Town Square Television.

Vixen history dates back to 1999, when businessmen Carter Turner and Terry Sullivan decided to explore the feasibility of a professional women's football league by gathering together top female athletes from across the United States and dividing them into two teams for a nationwide series of exhibition game.

The teams were named the Minnesota Vixens and the Lake Michigan Minx, and the "No Limits" Barnstorming Tour featured six games in such locations as Miami, Chicago, and New York.

The final exhibition game was played at the Hubert H. Humphrey Metrodome in Minneapolis (known worldwide as home to the National Football League's Minnesota Vikings).

While the Vixens lost the game by a score of 30–27, the tour's success inspired the expansion of the Women's Professional Football League to 11 teams in 2000.

The success of the tour led Turner and Sullivan to form the Women's Professional Football League;[3][2] although the Minx would not join the Vixen in the WPFL's first full season, the Austin Rage, Colorado Valkyries, Daytona Beach Barracudas, Houston Energy, Miami Fury, New England Storm, New York Galaxy, New York Sharks, Oklahoma City Wildcats, and Tampa Tempest would join the Vixen to form the WPFL's inaugural roster of teams.

The Vixen would finish the regular season unbeaten at 5–0, clinch the Central Division title, and ensure home-field advantage throughout the American Conference playoffs.

The Vixen finished 6–4 and second place in the National Conference, North Division, qualifying for the playoffs for the first time in four years.

However, that playoff run would only last one game, as the Vixen lost by a score of 31–7 to the North Division Champions and eventual NWFA runners-up West Michigan Mayhem.

In 2014, the Minnesota Vixen also established a relationship with Northwestern Health Sciences University as their Official Integrative Sports Care Provider.

The Vixen then hosted the New York Sharks at home stadium Simley Athletic Field setting a new attendance record of over 1,100 fans.

The new tradition of winning continued with the Vixen as they completed their twentieth season 7–1 and rolled through the playoffs to reach the WFA Division II National Championship.

After a first round bye in the playoffs, the Vixen then hosted the Wisconsin Dragons followed by the Mile High Blaze to become the WFA 2018 American Conference Champions and secure a spot in the national championship game where they faced the New York Sharks.

Furthermore, two long term Vixen players, Jessica Giesemann and Michele Braun retired from their playing careers to step into coaching roles with linebackers and offensive Line respectively.

Coach McCauley returned for his 2nd season and the Vixen moved home games to Concordia St Paul.