Mir Ghulam Ali Talpur (senior) was a Pakistani politician.

He got his school education from his native town, Tando Muhammad Khan.

Mir Ghulam Ali Talpur Sr. started his political career in 1936, when he contested in election from Badin – Tando Bago constituency.

He won this election and became a Member of the Legislative Assembly (MLA).

He became minister in Sir Ghulam Hussain Hidayat Ullah Sindh's cabinet from 28 April 1937 to 23 March 1938.