She also starred in the films Romy and Michele's High School Reunion (1997), Mimic (1997), Lulu on the Bridge (1998), The Replacement Killers (1998), Summer of Sam (1999), Gods and Generals (2003), Like Dandelion Dust (2009), and Sound of Freedom (2023).

For her work in television, she was nominated for a Primetime Emmy Award for Outstanding Lead Actress in a Limited Series or Movie for her portrayal of Marilyn Monroe in Norma Jean & Marilyn (1996) and nominated twice for a Golden Globe for Best Actress – Miniseries or Television Film for her performance as Detective Kate Morozov and for her leading role in Human Trafficking (2005).

[4] She was raised in Tenafly, New Jersey,[5] where she wrote and acted in backyard plays with her childhood friend Hope Davis, and in theater productions at Dwight-Englewood School.

After supporting roles in Robert Redford's Quiz Show and Whit Stillman's Barcelona, she was cast in Woody Allen's Mighty Aphrodite (1995).

"[7] Her other credits include Romy and Michele's High School Reunion with Lisa Kudrow, At First Sight with Val Kilmer, and Spike Lee's Summer of Sam.

[16] In 2006, she received a Golden Globe nomination for her role as an Immigration and Customs Enforcement agent in the Lifetime film Human Trafficking.

[17] She starred in Attack on Leningrad (2009), Multiple Sarcasms (2010) with Timothy Hutton and Stockard Channing, and Nancy Savoca's Union Square (2012), with Patti Lupone and Tammy Blanchard.

[19][20] In the same year, Sorvino played the mother of the lead in the film adaptation of Wendy Mass's popular children's book Jeremy Fink and the Meaning of Life.

[26][27] Between 1996 and 1998, Mira Sorvino was romantically involved with director Quentin Tarantino, who was her escort to the Academy Awards ceremony where she won Best Supporting Actress for Mighty Aphrodite.

[32][33] In September 2014, Sorvino gave a wide-ranging interview on The Nerdist Podcast, where she discussed her education, living in China, and her varied interests.

[39][40] According to Peter Jackson, Weinstein blocked Sorvino and Ashley Judd, another of his alleged victims, from being considered for parts in The Lord of the Rings films.