Mirabilis multiflora is a species of flowering plant in the four o'clock family known by the common names Colorado four-o'clock or desert four-o'clock that is native to the southwestern United States from California to Colorado and Texas, as well as far northern Mexico, where it grows in mostly dry habitat types in a number of regions.

Each fleshy leaf has an oval or rounded blade up to 12 centimetres (4.7 in) long and is hairless or sparsely hairy.

Mirabilis multiflora was given its first scientific description by the botanist John Torrey in 1827 with the name Oxybaphus multiflorus.

It is described by Asa Gray in 1853 as Quamoclidion multiflorum and in 1859 with the accepted name as Mirabilis multiflora.

[7] Among the Zuni people, the powdered root is mixed with flour, made into a bread, and used to decrease appetite.