The construction was commissioned to Juan de Colonia, and was continued after his death by his son, Simón de Colonia, who completed the structure in 1484 at the behest of Queen Isabella I of Castile, surviving daughter of king John II of Castile and queen Isabella of Portugal, whose impressive buried are housed in the monastery.

The Charterhouse is 3 km east of the city center of Burgos, in the parque de Fuentes Blancas, close to the Arlanzón River.

[3]With the arrival to the throne of the John II's daughter, Isabella I of Castile, return the work in monastery from the year 1477, undertaking new projects such as the Sepulchers of the Kings or the Altarpiece.

The floor develops from the placement of the church and the layout of two main cloisters for each of the groups of Carthusian monks who inhabit: Fathers and Brothers.

It consists of pointed archivolts decorated with plants, animals and some human figurative motifs located under a big ogee with poaceaes.

The main altarpiece of the Charterhouse was carved in wood by artist Gil de Siloé and polychrome and gilded by Diego de la Cruz (whose gold came from the first shipments of the Americas after its discovery)[4] Made between 1496 and 1499, is undoubtedly one of the most important existing works of the Spanish Gothic sculpture, by its compositional and iconographic originality and excellent quality of carving, valued by the polychrome.

One of the most important elements of the altarpiece is the angelic wheel in which is framed the Christ crucified image for its beauty and significantly accentuated expressiveness by the work of polychrome of Diego de la Cruz.

The pelican located at top of the cross gives the core set an extraordinary symbolic value as an allegory to the Eucharistic sacrifice, because the bird feeds its birdies of its own blood.

The royal sepulchers set were designed by artist Gil de Siloé commissioned by Queen Isabella I of Castile.