Tin, copper, arsenic, and gold mining took plece in the area, as is the case with the 'Buraco da Pala,' located in the parish of Passos.

Archaeological findings at Castelo Velho, São Martinho, Mourel, and Prado Pequeno include ceramics, manual millstones, tiles, and copper coins, one from the reign of Emperor Tiberius.

The resulting document Parochiale Suevorum displays the area of the municipality under a vast administrative region called "Laetera".

[4] On 2 September 1282, King Denis issued a royal decree, officially transferring the town to its current location in São Miguel Hill, where a small shrine existed.

Residents of the town that did not possess arms or a horse were mandated to pay annual stipend on São Miguel day, in September.

[5][6] Mirandela was donated to the Távora family in 1301 when King Denis granted the town's title to Branca Lourenço.

For several centuries, the Távoras held significant power in the region, contributing to the local economy and supporting institutions such as the Santa Casa da Misericórdia, where many family members served as administrators and benefactors.

The municipality would only reintegrate these areas, together with Torre de Dona Chama in the 19th century, reaching its modern day borders.

In 1963, during Estado Novo, an ambitious agribusiness development project, the Cachão Agroindustrial Complex, was established in Mirandela municipality.

Mirandela has a Mediterranean climate (Köppen: Csa) with hot dry summers and cool wet winters.

It includes a collection of artworks by Armindo Teixeira Lopes and other art pieces from the 20th century, most by Portuguese artists.

The museum's collection also includes artworks by the following artists: Nadir Afonso, Júlio Resende, Júlio Pomar, João Hogan, Graça Morais, Malangatana, Manuel Cargaleiro, Mário Cesariny, João Abel Manta, Antoni Tàpies, Almada Negreiros, Vieira da Silva, José Rodrigues and Ângelo de Sousa.