Darc's debuted in Claude Barma's television drama Du côté de l'enfer (aka, La Grande Brétèche, 1960).

Her first leading role came in another production for French television, Jean Prat's Hauteclaire (1961).

She starred in Jean-Luc Godard's film Weekend (Week-end, 1967)[3] as Corinne, her highest profile role for international critics; as Christine in The Tall Blond Man with One Black Shoe (Le Grand Blond avec une chaussure noire, 1972) and The Return of the Tall Blond Man with One Black Shoe (Le retour du grand blond, 1974) and alongside Alain Delon and Louis de Funès in several films: Pouic-Pouic (1963), High Lifers (Les Bons Vivants (1965), Jeff (1969), Borsalino (uncredited, 1970), The Love Mates (Madly, 1970), Icy Breasts (Les Seins de glace, 1974), Death of a Corrupt Man (Mort d'un pourri, 1977), Man in a Hurry (L'Homme pressé, 1977), and the television series Frank Riva [fr] (2003).

In the 1980s, Darc's career was interrupted by open-heart surgery following a car accident, in which she was seriously injured, and her separation from Alain Delon after fifteen years together.

In 2006, French President Jacques Chirac awarded Darc the Legion of Honour.