[6] The oldest of three siblings,[7] her sister Onutė Gražinytė is a pianist, and she has a younger brother, Adomas Gražinis.
As a child, Gražinytė-Tyla received her initial education in French and painting,[4] and studied at the National M. K. Čiurlionis School of Art in Vilnius.
[9] Gražinytė-Tyla chose to add the word 'Tyla', Lithuanian for 'silence', to form her professional name.
[15] In the US, Gražinytė-Tyla was a Gustavo Dudamel Fellow of the Los Angeles Philharmonic for the 2012–2013 season.
[16] In August 2015, the orchestra named her its new associate conductor, effective with the end of the 2015–2016 season, contracted through 2017.
[17] In July 2015, Gražinytė-Tyla first guest-conducted the City of Birmingham Symphony Orchestra (CBSO).
[19] In February 2016, the CBSO named her as its next music director, effective September 2016, with an initial contract of 3 years.
[25] In February 2019, Gražinytė-Tyla signed an exclusive long-term recording contract with Deutsche Grammophon (DG).