He played his final match in professional football on 2 June 2007 at MHSK Stadium in Tashkent against a combined team of European and Asian stars.

The match brought together famous players such as Iranian Ali Daei, his counterpart Alireza Mansurian, and ex-Qatar international Mubarak Mustapha, his former trainer from Alania, Valeri Gazzaev, Russian footballers Viktor Onopko and Andrei Karyaka.

On 25 September 2008 Brazilian legend, Zico was appointed as the new coach of Bunyodkor, Kasimov remained adviser-coach at club side.

On 16 September 2008, he became head coach of the Uzbekistan national football team for the qualification stage of the 2010 World cup.

[8] On 4 June 2012, Qosimov was appointed as the new head coach of the Uzbekistan national football team for the second time after Vadim Abramov resigned from his post (lost 0–1 against Iran at home).

[13] Qosimov resigned his post as Bunyodkor's head coach on 5 April 2014 to concentrate on his work in the national team.

But in next play-off round one leg match on 19 February 2019 lost to Al-Nassr 0:4 und failed to qualify to group stage tournament.

Individual Mirjalol Qosimov as Alania Vladikavkaz player performed 3 international appearances in UEFA tournaments.