Mirpur Khas Junction Railway Station (Urdu: میرپور خاص ریلوے اسٹیشن,Sindhi: میرپور خاص ریلوي اسٽیشن) is a junction located in the middle of the Mirpur Khas, Sindh, Pakistan on the Hyderabad - Khokhrapar branch railway line.

Before 1965, the Hyderabad-Khokhrapar Branch Line was metre gauge and Mirpur Khas railway station was the junction of Mirpur Khas - Nawabshah railway line.

In 1965 Hyderabad - Mirpur Khas railway section converted to broad gauge and the rail link between the Pakistan and India via Khokhrapar and Munabao closed.

In February 2006 Mirpur Khas - Khokhrapar metre gauge railway line converted to broad gauge and railway link between Pakistan and India via Khokhrapar and Munabao restored again.

The routes of Hyderabad Mirpur Khas branch line is linked from Karachi as follow : Karachi, Landhi, Dhabeji, Jang Shahi, Jhampir, Kotri,Hyderabad, Tando Jam, Tando Allahyar, Mirpur Khas, Dhoro Naro, Pithoro, Chorr, Khokhrapar.