Sultan Fakhruddin Mobarak Shah conquered Chittagong in 1340 AD and established Muslim rule in this region.

The place within the current Mirsharai thana where Bujurg Umed Khan, son of Subadar Sayesta Khan, landed after crossing the Feni River was named as Bujurg Umedpur.

With the conquest of Chittagong by Khan in 1666, the region came permanently under Mughal rule.

Towards the end of British rule in India, the Durgapur and Karerhat areas of Mirsharai were the centres of revolutionary activities of Chittagong.

A fierce battle was fought between the freedom fighters (under Captain Wali Ahmed) and the Pak Army near the Fenafuni Bridge on the south of Mirsharai sadar, in which about 100 Pak soldiers were killed.

[7][8] Mirsharai Upazila is divided into Baroiyarhat Municipality, Mirsharai Municipality, and 16 union parishads: Dhum, Durgapur, Haitkandi, Hinguli, Ichhakhali, Jorarganj, Katachhara, Khaiyachhara, Karerhat, Maghadia, Mayani, Mirsharai, Mithanala, Osmanpur, Saherkhali, and Wahedpur.