Grand Ayatollah Mujaddid Mirza Abu Muhammad Mu'iz al-Din Muhammad Hassan Husayni Shirazi (Persian: ابومحمد معزالدین محمدحسن حسينى شيرازی; Arabic: أبو محمد معز الدين محمد حسن الحسيني الشيرازي; 25 April 1815 – 20 February 1895), better simply known as Mirza Shirazi (میرزای شیرازی), was an Iranian Shia marja'.

[1] Najafi equipped Shirazi with another certificate of ijtihad and a letter of recommendation to Hossein Khan Sardar, governor of Iran.

After another attempt by Shirazi, that was also met with no response, a fatwa began to go around in Tehran, declaring the use of tobacco to be tantamount to war against the Hidden Imam, Muhammad al-Mahdi.

[12] His great-grandson, Radhi Shirazi narrates when the Sunnis decided to build a seminary for themselves, after reaching a specific stage, they had run out of funds to complete the construction.

[13] In 1893, when chaos began to spread across Samarra due to sectarian tensions, leading to the death of Shirazi's son, Muhammad, as well as one of his nephews.

In the meantime, the British and Russian governments both tried to take advantage of the situation and intervene by deploying their forces to one side of the conflict, choosing Shirazi.

[7] Shirazi produced a large number of prominent students that proved to be great scholars of the age, and had a huge impact on the dissemination of the Islamic sciences.

[20] The role he played in the tobacco boycott has been dubbed a "stunning" demonstration of the power of the marja'-i taqlid, and the protest itself has been cited as one of the issues that led to the Persian Constitutional Revolution a few years later.