[8] Doi also played the character in a console video game based on the first film that was released for the Sega Saturn in 1997 to celebrate the 15th anniversary of the Macross franchise,[9] and that was also ported to the PlayStation in 1999.

[10] In the English dub of the original Japanese series that was released by ADV Films in January 2006 the character was voiced by Monica Rial.

However, this mindset changed after she met the young pilot Hikaru Ichijyo, who at that time was in love with the soon-to-be superstar Lynn Minmay.

While they were still unsure of their own feelings, both felt deep loneliness after Misa departed Macross to Earth, trying to persuade the United Government to enter peace negotiations with the Zentradi troops.

Clumsy at communicating his feelings, Hikaru sent Misa the message "Wish you return to Macross safely" using the Morse code (Episode 24: Goodbye, Girl).

After Space War I, the love triangle of Misa-Hikaru-Minmay underwent many turns and Misa was deeply hurt by Hikaru's lingering feeling for Lynn Minmay.

Given the grand vision, political influence, and competence of Lady M in dealing with the New United Government and initiating the researches, the most likely candidate is Misa, the Commander of Megaroad-01 and the one who deciphered the lyrics of the song "Do You Remember Love."

She was the boss and commanding officer of the fighter pilot protagonist Hikaru Ichijyo (called Rick Hunter in Robotech), and later his love interest.

"[16] According to an article in Animerica magazine, Shoji Kawamori's original idea for the Macross series was an all-female crew for the battleship with a female captain at the helm.

She's a strong-willed, determined and down-to-earth type of woman, completely immersed in doing her duty; at the same time, these traits had made her unable to maintain romantic relationships, although, as seen in the series, she lets her feelings interfere with her work.

Catherine Glass of Macross Frontier physically resembles Misa Hayase, and is also shown to have trouble keeping up with a decent love life.