[2] In Autumn 2012, she supported American rapper Nicki Minaj on the United Kingdom leg of her Pink Friday: Reloaded Tour and was nominated as Best Newcomer at the MOBO Awards.

[14] Misha B began to take her vocals abilities more seriously aged fourteen - describing music as her only outlet[15] and saying that singing assisted her self-understanding.

In her first audition in front of judges Louis Walsh, Gary Barlow, Kelly Rowland and Tulisa, she sang Aretha Franklin's cover of "Respect".

[22] Noted for her "Lauryn Hill-like rap-singing style", she progressed through to bootcamp and then to judges' houses, where she was put through to the live shows by Rowland in her Girls category (solo females aged 16–24) alongside Amelia Lily, Janet Devlin and Sophie Habibis.

[15] A variety of sources including The Daily Telegraph, Digital Spy and bluesandsoul.com have regarded Misha B as one of the more gifted and exciting acts ever to have come out of a talent competition.

[20][23] BBC 1xtra noting her "show-stopping performances", considered her to be one of the most credible artists to emerge from the show and a "break from the traditional X Factor contestant".

After receiving the fewest votes in the semi-final in week 9, Misha B was eliminated from the show and finished in fourth place.

[33] Whilst on the tour, Misha B spent time working on her first mixtape, Why Hello World, mixed by DJ Stylus[34] and released for free download on 27 April.

[43] She also performed "Home Run" at the BBC 1Xtra Live 2012 concert at the Manchester Apollo, singing Adele's "Rolling in the Deep" and a new song "Runway";[44] duetting with Daley on his single Remember Me covering for Jessie J.

[50] In October, performed an acoustic version for Trevor Nelson's 1Xtra Live Lounge, plus a cover of Labrinth and Emeli Sande's "Beneath Your Beautiful".

"[54] In January 2013, Misha B headlined the half-time show for the American National Basketball Association (NBA) game between the Detroit Pistons and New York Knicks in London.

[58][59] On 12 February, she released her second mixtape, Knock Knock, which contained six snippets of original songs (including "Here's To Everything", "Alien Avenue / I Need a Dollar", "Ugly Love" and "Silent Cry") and two covers Otis Redding's "Respect" and an a cappella version of American girl-group SWV's song "Weak".

[60] During 2013, Misha B performed at various locations including Clyde Auditorium,[61] the farewell party for Lord Mayor Gavin Robinson[62] and the JLS Foundation and Cancer Research UK fundraiser in London.

[66] On 10 August, she sang the National Anthem at Wembley Stadium for the annual FA Community Shield fixture.

[70] In September, Misha B joined Krept and Konan in an acoustic session for SBTV of their "disturbingly evocative" autobiographical rap "My Story" from their UK top ten album charting "Young Kingz" mixtape.

[75] For the delayed album she has collaborated with Emeli Sandé, MNEK, Mr Hudson, TMS, Cutfather and Naughty Boy.

"[83] Misha B has been compared to several female artists, grammy.com noted that her singing and rapping abilities were similar to Lauryn Hill.

[15] She has also been compared to Missy Elliott, Chaka Khan, Jennifer Hudson, Nicki Minaj, Tina Turner, Grace Jones and Eartha Kitt.

[84] SoulBounce described her vocals as "stylistically speaking... falling in line somewhere between Missy Elliott's quirkiness and Lauryn Hill's raw soulfulness".

[88] Regarding her own releases Home Run is a fusion of multiple genres – R&B, hip-hop, dance, pop, soul, reggae, drum and bass, combined with Misha's 'soulful vocals'.

"[97] Bryan also included rap breaks in her covers of Adele's "Rolling in the Deep" and Cyndi Lauper’s "Girls Just Want To Have Fun" while she was on The X Factor.

In December 2012, Misha B appeared in "The Taking Care of Christmas" on 4Music (as part of a partnership with youth charity vinspired) which highlighted the benefits of volunteering for a good cause and how it can make job applicants more attractive to prospective employers.

As a reward for helping others, the pupils win the chance to attend the Rock Assembly concert at Wembley in which Misha B along with other artists performed in 2013 and 2014.