The animals and birds that lived in the region were squirrel, mole, beaver, shrew-mouse, coyote, puma, deer, woodpeckers, white-winged doves, owl, and wild ducks, among others.

San Vicente was the center of operation on the Dominican missionary frontier and for that reason was protected by 12 to 25 soldiers from the Loreto presidio in what is now Baja California Sur who lived in a walled compound.

This Native American group belongs to the Yuman language family, and their territory extends from the Pacific coast over mountains and deserts to the Gulf of California.

Today there are 300 Paipai (or Jaspuy Paium as they call themselves) living in two communities: Santa Catarina in the Sierra Juárez and San Isidoro to the south near Trinidad Valley.

Efforts to preserve and restore this site have been included in the "Camino Real Misionero de las Californias" program of Mexico's National Institute of Anthropology and History (INAH).

The remains of the walls are covered by a sacrificial layer made of clay, sand, water, slices of nopal cactus, and manure to protect them from the wind, sunlight, and rain.