Fortún Ximénez, mutineer on an expedition sent by Hernán Cortéz, landed at La Paz in 1533.
Isidro de Atondo y Antillón and Eusebio Francisco Kino attempted to establish a mission settlement in 1683 but again failed because of conflicts with the native inhabitants.
When Jesuit missions finally took root in Baja California after 1697, the initial focus of activity was to the north, in the area around Loreto.
The Jesuits finally returned to the site of Airapí (probably a Guaycura name) in 1720, in coordinated expeditions from Loreto that traveled both by sea (under Ugarte and Bravo) and overland (under Clemente Guillén).
It was sacked in the Pericú Revolt of 1734 and finally abandoned in 1748, when its Indian neophytes were relocated to Todos Santos.