The series, set in Koshigaya, Saitama Prefecture, follows a female office worker who discovered a young dragon who has the ability to transform into a humanoid girl and was hired as her maid living in a apartment.

As office worker and programmer Kobayashi gets ready for work, she is greeted by a large dragon right outside her front door.

[27] A second spin-off drawn by Ayami Kazama, titled Miss Kobayashi's Dragon Maid: Elma's Office Lady Diary (小林さんちのメイドラゴン エルマのOL日記, Kobayashi-san Chi no Meidoragon: Elma OL Nikki), began serialization in Monthly Action on 25 August 2017.

[30] A fourth spin-off series drawn by Nobuyoshi Zamurai, titled Miss Kobayashi's Dragon Maid: Fafnir the Recluse (小林さんちのメイドラゴン お篭りぐらしのファフニール, Kobayashi-san Chi no Meidoragon: Okomori Gurashi no Fafnir) began serialization in Monthly Action on 25 November 2020.

[32] A fifth spin-off series drawn by Kometsubu, titled Miss Kobayashi's Dragon Maid: Iruru Has No Clue About Love!

Yuka Yamada handled series composition, Miku Kadowaki designed the characters, Nobuaki Maruki served as chief animation director, and the music was composed by Masumi Itō.

The opening theme is "Aozora no Rhapsody" (青空のラプソディ, "Rhapsody of Blue Sky") by Fhána, and the ending theme is "Ishukan Communication" (イシュカン・コミュニケーション, "Interspecies Communication") by Chorogons (Tohru (Yūki Kuwahara), Kanna Kamui (Maria Naganawa), Lucoa (Minami Takahashi), and Elma (Yūki Takada)).

[38] Titled Miss Kobayashi's Dragon Maid S (小林さんちのメイドラゴンS, Kobayashi-san Chi no Meidoragon S), the season aired between 8 July and 23 September 2021.

by Fhána, and the ending theme for the first 11 episodes is "Maid With Dragons" by Super Chorogons (Tohru (Kuwahara), Kanna Kamui (Naganawa), Lucoa (Takahashi), Elma (Takada), and Ilulu (Tomomi Mineuchi)).

[14] Crunchyroll simulcasted the series outside of Asia as it aired while Funimation released an English dubbed version from 1 February 2017.

Choro-gon Breath, it was released on 24 March 2022 on Nintendo Switch and PlayStation 4 in Japan,[52] followed by a worldwide launch by Aksys Games on the same consoles on 25 August 2022.

[54] In October 2019, a mother in Omaha, Nebraska was upset that her 11-year-old daughter checked out the manga from the Monroe Middle School's library which this series contained suggestive scenes.