It is also the first of only three films directed by Trevor Moore before his death in 2021, the second being "The Civil War On Drugs" which was aired in segments in the final season of The Whitest Kids U' Know in 2011, and the third being the animated comedy “Mars” which is set to be released posthumously.

Tucker has been a huge fan of the Playboy franchise since finding his friend Eugene's older brother's magazines when he was eight.

Tucker wakes Eugene from the coma with a baseball bat, and they discover that Cindi has become the newest Playboy centerfold.

Tucker's girlfriend, Candace, also begins hunting him down after an incident where he stabbed her after she bit his genitals during an epileptic seizure while performing fellatio.

The four make a deal where the boys do the driving to Los Angeles while the women are in the back seat having sex.

Hugh soon calls security upon learning that Tucker not only stabbed his girlfriend in the face with a fork, but the fact that firefighters want to kill him.

After Cindi reveals to everyone outside that Horsedick was born without genitals, his right-hand man realizes that he's never seen MPEG in action with a woman.

Horsedick leaves embarrassed and ashamed, and after Eugene and Cindi make up, Hefner lets everyone back in.

Trevor Moore and Zach Cregger were offered the script of Miss March by Fox, and although not initially interested, the idea held some appeal and they took it on as a writing exercise and made it their own.

[4] Robert Wagner was originally cast as Hugh Hefner and according to Moore and Cregger, he did a great job, but audiences at test screenings did not react positively; audiences already familiar with Hefner from the television series The Girls Next Door did not connect with Wagner.

Fortunately, Hefner liked what he saw and agreed to take part, as well as getting 2007 Playmate of the Year Sara Jean Underwood to cameo in the film.

For his performance in the film, Playboy founder Hugh Hefner was nominated for a Razzie Award for "worst supporting actor".

Cregger has stated he believes they did the best they could with the idea, and although some scenes work, the film was their first attempt at making a movie.