It was initially scheduled to premiere on LIVE 105 on April 13, 2006; however, it was released early due to overwhelming fan reaction.

[6][7] It is the band's most commercially successful single to date, reaching number 24 on the Billboard Hot 100 and topping the Alternative Songs chart.

The song originated with guitarist Jade Puget playing a bass hook on his guitar and vocalist Davey Havok coming up with the "Miss Murder" lyric as a throwaway line which ended up sticking.

Havok refuses to confirm or deny any rumors: "I don't necessarily need for people to understand specifically what it means.

"[11] A music video directed by Marc Webb for the song premiered on television shortly after the track's release.

The music video opens with Davey Havok finding a note, possibly written by Miss Murder.

Havok then appears on a balcony, rallying a chanting crowd below, and unfolds large posters of the band members themselves.