At the end of the event, Elle Smith of Kentucky crowned R'Bonney Gabriel of Texas as Miss USA 2022.

At the age of 28 years, 6 months and 13 days, Gabriel became the oldest Miss USA winner in the pageant's history, surpassing Cheslie Kryst in 2019, who was also 28 when she crowned, and the first titleholder of Filipino descent.

The competition was hosted by Zuri Hall for the second consecutive year, while Julissa Bermudez and Micah Jesse served as sideline correspondents.

[8] On 14 July 2022, it was reported that the competition would be held in Reno, Nevada, with the city securing a three-year deal to host the pageant.

National Director Crystle Stewart confirmed that the location was chosen to honor Cheslie Kryst, whom had been crowned Miss USA 2019 in the same venue and had died by suicide in January 2022.

In September 2022, prior to the national competition, state officials had expressed concern that Stewart, as the most recent Miss Texas USA winner to win the national-level competition, was providing preferential treatment to the 2022 Miss Texas USA winner, R'Bonney Gabriel.