They pose as a married couple to obtain jobs in a high school founded by Gopal, the zamindar of Aandipettai.

C. P. Jambulingam and Kalyanam edited the film; Marcus Bartley was the cinematographer, and S. Rajeswara Rao composed the music.

By circumstances he meets an unmarried young girl who is looking for a way to earn some money to set off a loan taken by her father.

B. Nagi Reddy and Aluri Chakrapani signed L. V. Prasad to direct a bilingual film for Vijaya Vauhini Studios.

The film's script, by Chakrapani, was based on Rabindranath Maitra's Bengali play Manmoyee Girls School.

[2] Prasad's relationship with Khan, a Muslim tailor near Kohinoor Studios in Bombay (now Mumbai), was the basis of the film's friendship between two men of different religions.

[4] Although Pathala Bhairavi (1951) and Pelli Chesi Choodu (1952) were the first bilingual films shot in Telugu and Tamil, the same actors were used in both versions.

[5] S. V. Ranga Rao and Rushyendramani and Doraswamy and Meenakshi were cast as the title character's biological and foster parents, respectively, in both versions.

[9] Savitri benefited the Tamil version by improving the on-screen chemistry with Ganesan; they had secretly married in 1952, before filming began.

[10] K. A. Thangavelu and K. Sarangapani reprise the roles that Akkineni Nageswara Rao and Relangi played in Telugu.

[12] For one sequence in his character jumps from a balcony, Ganesan refused a stunt double and performed the scene himself.

[7] After they saw the final edited version, Nagi Reddy and Chakrapani gave Dodge automobiles to the film's principal cast.

[21] Songs like "Vaarayo Vennilaave", "Brindavanamum Nandakumaranum", "Ennai Aalum Mary Maatha" and "Pazhaga Theriyavenum" became popular with the Tamil diaspora.

[2][7][17] According to Swarnavel Eswaran Pillai's 2015 book Madras Studios, speculation about Savitri's real-life romance with Ganesan played a key role in the success of the film.

[28] A postage stamp commemorating Ganesan was introduced in Chennai in February 2006 by Dayanidhi Maran (the-then Minister of Communications and Information Technology) and Missiamma was shown for the occasion.

[29] The February 1955 issue of Kumudam called Missiamma "an interesting film with quality humor": "In the beginning one is uneasy as to how the love affair of a Christian heroine and a Hindu hero is going to be retooled for a comedy", but Prasad "has used every difficult situation as an opportunity for boundless humor".

Prasad : a monograph (1993), film historian K. N. T. Sastry wrote: "lf cinema was to be considered a tool to forget our worries — here indeed was entertainment: Missiamma answered that definition.

[32] Gemini Ganesan reprised his role in AVM Productions' Hindi remake of the film, Miss Mary, which marked his Bollywood debut.

[34] On 23 January 1955, a 19-year-old woman gave birth to a baby in the Roxy Theatre in Madras while watching Missiamma.