"Missing Piece" made its television debut in the seventeenth season of American medical drama Grey's Anatomy.

At the 2021 ARIA Music Awards, the song won Best Video for Annelise Hickey's directed video; "Missing Piece" was also nominated for Song of the Year, Best Pop Release and Best Independent Release; Vance Joy was nominated for Best Artist.

"[5] Joy promoted the single with merchandise including an embroidered blue jumper and a white t-shirt featuring the running woman shown on the cover art.

[8] Joe Vitagliano from American Songwriter called the song "a heartfelt indie-folk anthem" saying "From its sentimental lyrics to its anthemic melodies, the single feels like a perfect match for a variety of meaningful life moments.

"[9] On 20 May 2021, it was announced that "Missing Piece" would debut in the seventeenth season of American medical drama Grey's Anatomy.