The mission was by the Domingo Ramón-St. Denis expedition[2] and was originally meant to be a base for converting the Hasinai to Catholicism and teaching them what they needed to know to become Mexican citizens.

[5] In 2015, the United Nations Educational, Scientific, and Cultural Organization designated Concepción and four other San Antonio missions, including The Alamo, as a World Heritage Site, the first in Texas and one of twenty-three such establishments in the United States.

When originally built, brightly painted frescos decorated both the exterior and interior of the building.

The Archdiocese of San Antonio completed another restoration of the mission's interior in 2010 which exposed more frescoes in the sanctuary and nave.

The western entrance to the church is aligned to the sunset in such a way that an "annual double solar illumination event" occurs every year on or around August 15, the feast day of the Assumption of Mary.