It hosted the WCW Beach Blast in 1993 and the Sun Belt Conference men's basketball tournament in 1992 and 1993.

In addition, the rematch between legendary boxing former world heavyweight champion Larry Holmes and his fellow former world heavyweight champion Mike Weaver was held at the Coast Coliseum on November 17, 2000; Holmes winning by sixth-round technical knockout.

[3] The first concert held at the Mississippi Coast Coliseum was by Charley Pride on November 18, 1977, while the first rock band to perform was Blue Öyster Cult on April 16, 1978.

Due to damages to the arena by heavy flooding and winds from Hurricane Katrina in August 2005, the Sea Wolves cancelled their 2005–2006 and 2006–2007 seasons.

[5][6] In 2021, the Federal Prospects Hockey League hosted three neutral site games in Biloxi and an ownership group announced a new Sea Wolves team would begin playing in the 2022–23 season.

The Mississippi Beach Kings, under the leadership of general manager Roy Turner and coach Gary Hindley, went 18–10 during the 1998 season in the Eastern Indoor Soccer League.

The Mississippi Fire Dogs of the National Indoor Football League also played at the arena, folding in 2003.

Miranda Lambert has performed in the venue multiple times, most recently being during her Wildcard Tour in early 2020.