The eastern segment starts at MS 4 near Ripley and it travels northeastwards towards Corinth.

The section west of Corinth became a part of US 72 by 1935, and the route was extended southwestwards to Hickory Flat by 1958.

In 2012, Mississippi Department of Transportation (MDOT) calculated as many as 2,400 vehicles traveling west of MS 15 and MS 368, and as few as 1,100 vehicles traveling west of the eastern boundary of the Holly Springs National Forest.

East of Flat Rock Road, MS 2 leaves the national forest boundary.

[2][7] The route continues the bend north and south, until it reaches County Road 821 (CO 821), where it straightens out.

Near the eastern terminus, the road dips slightly to the south and becomes West Palmer Street.

The route travels northeast through large sections of forests, and intersects MS 773.

Southwest of Corinth, the route intersects CO 613, a short road to Roscoe Turner Airport.

[3][9] The two routes continue eastward, intersecting Norman Road and travelling towards downtown Corinth.

The road intersects US 45 at a diamond interchange, and MS 2 begins travelling northward along with US 45, while US 72 continues eastward.

US 45 and MS 2 bypass Corinth, with an interchange at Wenasoga Road northeast of the town center.

The majority of the route was layered in gravel, with only the section from Corinth to the state line paved in asphalt.