The route is located in northeastern Covington and southern Smith counties.

[1] MS 37 starts at the three-way junction with US 84 east of Collins in Covington County,[3] and it travels northward through a forested area.

[3] It intersects MS 532 in the unincorporated area of Hot Coffee,[6] and it crosses Oakohay Creek north of Calhoun Church Road.

[4] South of Old Gilmer Road, the route enters the city limits of Taylorsville.

The route turns northwestward at Magnolia Drive and leaves the city limits.