The Mississippi Lofts and Adler Theatre is an apartment building and theater complex located in downtown Davenport, Iowa, United States.

It is individually listed on the National Register of Historic Places by its original name, the Hotel Mississippi and RKO Orpheum Theater.

Its grand opening was held on November 25, 1931, with Ginger Rogers sending a telegram from Hollywood to begin the ribbon-cutting ceremony.

Her movie, Suicide Fleet, and five vaudeville acts accompanied by the theater's house orchestra were the opening night entertainment.

Because of its size and modern facilities, the Orpheum became the Tri Cities cinema showplace, and it hosted all of Hollywood's major releases.

[5] Entertainers such as Tallulah Bankhead, Paul Robeson, Imogene Coca, Dorothy Lamour, Phil Ford, Forrest Tucker, John Barrymore, Liberace, Ella Fitzgerald, Pearl Bailey, Jack Benny, Sammy Cahn, Phyllis Diller, Jimmy Dean, Stan Kenton, The Beach Boys, Sonny & Cher, The Supremes, and The Pointer Sisters and KISS, performed in the theater live.

However, the stylized geometry indicative of the Art Deco style is found on the horizontal banding that defines the tenth floor.

The lobby ceiling is a series of recessed stepped pyramid openings that are arranged in a large rectangular panel.

Two large chandeliers with crystal strands form geometric patterns that are consistent with the theater's Art Deco style.

[6] The Davenport architectural firm of Scholtz-Kuehn and Paul S. Veneklasen, an acoustics consultant from Santa Monica, California were responsible for the plans.

They had been newspaper publishers and philanthropists in Davenport and the decision to rename the theater was based on a $1.3 million endowment from Lee Enterprises, the company they led.

The renovations also included a new loading dock, additional dressing rooms, improved sound and computerized rigging systems.

The project restored its multi-colored terrazzo floors, Art Deco-style elevator doors, and walnut and teak wood paneling.

The 2010 marquee was replaced in April 2018 by a new $340,000 structure designed by Michigan architect Eric Larsen and built by Wagner Electric Sign Company of Elyria, Ohio.

It features two 30-foot (9.1 m) angled panels with LED screens that advertise upcoming shows, and a 36-foot (11 m) vertical blade sign with the theater's name.